Parana NICARBMIX 50%
1 g of the drug contain:
Nicarbazin 500 mg
Dosage:
As anaid inprevention of deaths due to coccidiosis inchickens under conditions of
mild exposure: 150 g -250g/ 1T feed.
As an aid inprevention of deaths due to coccidiosis inchickens: 200g-300g/1T feed.
As an aid inpreventing deaths due tococcidiosis while immunity to this disease is
developing in replacement chickens, 8 weeks of age or over: 160g/1T feed from 8
weeks of age or over, until birds are moved to laying house.
Description:
Nicarbazin 50% is acoccidiostat used on meat chickens. It is also used as acontraceptive for population control of Canada geese andferal pigeons. Nicarbazin Premix
can kill the second-generation schizonts and trophozoites,reducing intestinal cell
damage.
Pharmacological properties:
Nicarbazin is active against all coccidia species parasitizing in poultry including E.
acervulina, E. necatrix, E. tenella, E. brunetti, E. maxima, E. mivati, E. mitis, and E.
рrаесох.
Nicarbazin is a synthetic anticoccidial agent, which is a complex of components of
4,4’- dinitrodiphenylurea (DNC) and 2-hydro-4,6 dimethylpyrimidine (HDP).
Mode of action: nicarbazine inhibits the energy metabolism in the body of
aparasite. Having anticoccidial properties, it interrupts the life cycle of coccidia at
different stages of development; it is most active at the stage of second-generation
schizonts.
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Nicarbazin is poorly absorbed in the gastrointestinal tract and exerts itanticoccidial
action in the mucous membrane and in the submucosal layer of the intestine.
Nicarbazin is excreted from the bird body mainly unchanged with excrements
within 6 to 8 days.
Cution:
Do not feed to laying chickens. Do not use as a treatment for outbreaks of
coccidiosis. Do not use influshing mashes. If losses exceed 0.5 percent in a 2-day
period, obtain anaccurate diagnosis and follow the instructions of your veterinarian
or poultry pathologist. Broilers fedfeed medicated with nicarbazin 50% may show
reduced heat tolerance when exposed to hightemperature and high humidity to
which they have not been accustomed and under severe conditions, fatalities may
result. An ample supply of drinking water andadequate ventilation will improve the
birds’ tolerance of heat.
Withdrawal times:
Poultry slaughter for meat is possible in 5 days following the last administration
of the drug. Meat, obtained before the mentioned term shall be utilized or fed to
non-productive animals depending on the statement of a veterinary physician
Storage:
Store in dry and dark place at temperature below 30° C.
