Parana TIDOX ws
1 g of the drug contains:
doxycycline hyclate 200 mg
tiamulin (tiamulin hydrogen fumarate) 66 mg
Dosage:
Orally with feed or drinking water in the following doses:
swine: – 0.5-1 kg of the drug per 1000 kg of feed or 0.25-0.5 kg of the drug per
1000 l of drinking water once a day for 7 days.
hens (chickens, broiler chickens) and turkeys -0.25-0.5 kg of the drug per
1000 kg of feed or 0.125-0.25 kg of the drug per 1000 l of drinking water once a day
for 7 days.
Description:
Doxycycline is a broad-spectrum bactericidal antibiotic of the tetracycline group.
It is effective against gram-positive and gram-negative baccteria (Staphylococcus
spp., Streptococcus spp., Bac. аnthracis, Clostridium spp., Listeria spp., Actinomyces spp., Klebsiella spp., Shigella spp., Yersinia spp., Bordetella spp., Campylobacter spp., E. coli, Haemophilus spp., Pasteurella spp., Salmonella spp.), chlamydiae
(Chlamydia spp.), mycoplasma (Mycoplasma spp.) and rickettsiae (Rickettsia spp.).
Doxycycline inhibits synthesis of microbial cell proteins, binding receptors of ribosomal 30S subunit in microorganisms. It blocks attachment of aminoacyl tRNA to
acceptor site, preventing attachment of new amino acids to peptide chain and preventing in such way synthesis of microbial proteins.
Tiamulin is a semi-synthetic antibiotic of the diterpenes group. It is effective
against gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp.,
Corynebacterium spp., Erysipelothrix spp., Listeria spp.) and certain gram-negative
microorganisms (Haemophilus influenzae, Pasteurella multocida, Actinobacillus
pleuropneumoniae, Campylobacter spp.), spirochetes (Serpulina hyodysenteriae,
S. innocens, S. pilosicoli, S. suis), as well as Lawsonia intracellularis. The mechanism
of its antibacterial activity consists in inhibition of bacterial protein synthesis at the
level of ribosomal 50S subunit.
After oral administration, doxycycline is well absorbed from the digestive tract and
reaches its maximum serum concentration in 2 hours. It penetrates into lungs, thus,
it is effective in treatment of respiratory infections. Feed in digestive tract does not
affect doxycycline absorption. Antibiotic bioavailability is 50-80 %. Doxycycline is
well dissolved in lipids and distributes in most tissues. It is subject to minor biotransformations before excretion. Half-life in chickens makes 4.8 hours, in swine3.9 hours. Doxycycline, unlike other tetracyclines, is released into intestinal tract in
large amount and inactivated. Out of 90% of the substance 16% is excreted in urine,
about 5% – in bile, the rest is excreted intestinally.
Tiamulin is quickly absorbed from digestive tract and penetrates into all swine organs and tissues, its maximum concentration is observed in 2 hours following administration. The antibiotic is primarily excreted in feces
Indications:
Swine:Treatment of dysentery, atrophic rhinitis, enzootic pneumonia, actinobacillosis pleuropneumonia, hemophilosis, intestinal spirochetosis, salmonellosis, colibacteriosis, necrotic enteritis, caused by microorganisms sensitive to tiamulin and
doxycycline.
Hens (chickens, broiler chickens) and turkeys: Treatment of diseases of digestive
tract and respiratory organs caused by tiamulin – and doxycycline-sensitive microorganisms (Mycoplasma gallisepticum, Mycoplasma synoviae and Mycoplasma meleagridis).
Contra-Indication:
Do not administer to animals with hypersensitivity to tetracyclines and tiamulin as
well as to animals with kidney and liver disorders.
Avoid administration of drugs containing monensin, maduramycin, narasin, lasalocid or salinomycin at least in 7 days prior to, during and in 7 days following administration of tiamulin as this may cause deterioration in health condition or even
death.
Do not administer in combination with penicillins, cephalosporins, quinolones,
erythromycin, sulfonamides, chloramphenicol and chlorpromazine as well as with
drugs, containing magnesium, calcium and aluminum cations, as the latter bind to
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doxycycline and prevent its absorption.
Do not administer to hens and turkeys, laying eggs for human consumption
Whithdrawal Period:
Animal slaughter for meat is possible in 10 days following the last administration
of the drug. Meat, obtained before the mentioned term shall be utilized or fed to
non-productive animals depending on the statement of a veterinary physician.
Doxycycline as the drug component may cause structural changes in liver and kidneys, diarrhea.
It is recommended to avoid drug administration in combination with antacids, oxidants and kaolin.
Storage:
Store in a dry, dark place out of the reach of children at 5-30°С.
Shelf life
18 months.
Shelf life is 24 hours after dissolution in drinking water.
Shelf life after mixing with feed is 7 days.
