Parana COLI 2000 oral
1 ml of the drug contain:
Colistin sulphate 2000000 IU
Dosage:
For oral administration
Calves, goats and sheep: Twice daily 1 ml per 40 kg body weight for 5 – 7 days.
Poultry and swine: 1 litre per 2000 – 4000 litres of drinking water for 5 – 7 days.
Only sufficient medicated drinking water should be prepared to cover daily requirements.
Medicated drinking water should be replaced every 24 hours.
Note: for pre-ruminant calves, lambs and kids only.
Description:
Colistin is an antibiotic from the group of polymyxins with bactericidal action against
Gramnegative bacteria like E. coli, Haemophilus and Salmonella spp. Polymyxins interact strongly with phospholipids and penetrate into and disrupt the structure of
cell membranes. They disorganise the outer membrane of Gram-negative bacteria
by binding lipopolysaccharide (LPS, endotoxin) through direct interaction with the
anionic lipid A region, thereby neutralising the endotoxin capacity of LPS. Colistin
sulphate is poorly absorbed after oral administration, and serum concentrations
are generally undetectable. In chickens, residues in serum were detectable for up
to 6 hours after administration in the drinking water. Orally administered colistin is
eliminated almost totally in faeces.
Indications:
Coli 2000 Oral is indicated for gastrointestinal infections caused by colistin sensitive microorganisms like E. coli, Haemophilus and Salmonella spp. in calves, goats,
sheep, poultry and swine.
Contra indications:
Cases of hypersensitivity to colistin or to any of the excipients.
Administration to animals with seriously impaired renal functions or with an active
microbial digestion.
Administration in subtherapeutic doses or in cases of resistance to colistin.
Side effects:
Digestive alterations may appear, such as intestinal dysbiosis, accumulation of gases or mild diarrhoea. Overdoses may result in renal failure.
Withdrawal times:
– For meat: 7 days.
