Parana GENTA 10% ws
1 g of the drug contains:
gentamicin sulfate 100 mg
Dosage:
Orally with drinking water or feed in following doses dose:
swine: 5 g per 100 kg body weight (5 mg of gentamicin sulfate per 1 kg body weight)
once a day (divide into 2 administrations). Duration of treatment –3-5 days.
Calves (under 3 months old):5 g per 100 kg body weight (5 mg of gentamicin
sulfate per 1 kg body weight) daily (divide into 2 administrations with interval of 12
hours). Duration of treatment –3-5 days.
Poultry (broilers, brood hens, pullets): 5 g per 100 kg body weight (5 mg of
gentamicin sulfate per 1 kg body weight) once a day. Duration of treatment – 5-7
days.
Description:
Gentamicin is an aminoglycoside antibiotic. It makes bactericidal effect upon
gram-negative and, partially, upon gram-positive bacteria: Enterobacter aerogenes,
E. coli, Klebsiella spp., Neisseria spp., Pasteurella multocida, Pseudomonas aeruginosa, Salmonella spp., Serratia marcescens, Shigella spp., Staphylococcus spp.,
окремі Streptococcus species і Proteus species, Serpulina (Treponema) hyodysenteriae, Mycoplasma spp., Corynebacterium spp., Bacillus spp., Clostridium spp.,
Lysteria monocitigenes. Gentamicin penetrates into cell by way of oxygen-dependent active transport and passive diffusion. Then it binds to protein receptors
at the level of ribosomal 30S subunits and blocks formation of a complex, which
includes mRNA, formylmethionine and tRNA. Consequently, there appears incorrect
translation of tRNA, which results in formation of non-functional proteins.
It is poorly absorbed in blood and therefore acts only in organs of digestive system.
Gentamicin does not demonstrate any toxic effect upon organisms of animals, does
not cause any negative implications even in cases of major overdosing. Gentamicin
is scarcely biotransformed in digestive tract and is excreted unchanged in feces.
Indications:
Treatment of swine, calves (of up to 3 months of age), poultry (broilers, breeders,
pullets) against diseases of digestive tract (colibacteriosis, salmonellosis, dysentery,
campylobacteriosis) caused by gentamicin-sensitive microorganisms.
Contra-Indication:
Do not administer to animals with hypersensitivity to gentamicin. Do not prescribe
the drug in combination with or subsequently to other oto- or nephrotoxic drugs
(streptomycin, kanamycin, apramycin, neomycin, chloramphenicol) as well as
diuretic and muscle relaxants. Do not administer to animals with kidney function
disorders, ear and labyrinth disorders.
Withrawal Periode:
Animal slaughter for meat is allowed as follows: calves, swine – in 10 days, broilers, brood hens, pullets – in 14 days following the last administration. Meat,
obtained before the mentioned term shall be utilized or fed to non-productive animals
depending on the statement of a veterinary physician.
If administered with feed, mix the drug with the feed thoroughly. It is
recommended to mix it with 3-10 % of the total feed first, then mix the resulting
mixture with the remaining feed.
Storage:
Store in a dry, dark, damp-proof place out of reach of children at 0-30°С.
