Parana SPECT 100 ws
100 g of the drug contains:
lincomycin hydrochloride – 33,300 mg
spectinomycin sulfate – 66,700 mg
Dosage:
Orally with drinking water in the following doses:
Piglets: 10 mg of the drug per 2 kg body weight one a day (1.5 g of powder per
150 kg body weight) or 1000 g of the drug per 2000 l of drinking water. Duration of
treatment: 4-7 days;
Broiler chickens, brood hens, pullets: 100 g of the drug per 150-200 l of drinking water for 5-7 days.The drug solution shall be the only source of drinking water
throughout the whole treatment period!
Description:
SPECT 100 is a complex drug, containing lincomycin and spectinomycin. The drug
has a wide range of antibacterial action. The combination of lincomycin and spectinomycin has a potentiating effect on bacteria.Lincomycin is a lincosamide antibiotic. It
inhibits protein synthesis in microorganisms, binding ribosomal 50S subunits of
bacterial cells. It has a bacteriostatic or bactericidal effect, depending on the concentration.
It acts primarily against gram-positive (Staphylococcus spp., Streptococcus spp., Bacillus
anthracis, Corynebacterium spp.) and gram-negative (Actinobacillus spp.,
Bordetella spp., Nocardis spp., Actinomyces spp.) microorganisms. It is particularly
effective against Serpulina hyodysenteriae and
Mycoplasma spp.Spectinomycin is a tricyclic structure antibiotic of aminoglycosides.
The efficiency of action consists in inhibition of protein synthesis in microbial cell by
binding 30S ribosomal subgroups of microorganisms to prevent polypeptide chain
prolongation at the translocation stage. It acts primarily against gram-negative
and gram-positive microorganisms (E. coli, Pasteurella multocida, Salmonella spp.,
Clostridium spp., Erysipelothrix
rhusiopathiae, Haemophilus spp., Vibrio spp.), as well as mycoplasma (Mycoplasma
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spp.).After oral administration, lincomycin is well absorbed from digestive tract (almost
60%) and distributed in organs and tissues, including the bone tissue. Lincomycin binds
with proteins up to 50%. Lincomycin concentration in serum reaches its maximum in 2
after administration. Its half-life makes 2.5-4 hours. Most of lincomycin and its metabolites are primarily excreted in urine and bile. Small amounts are excreted in feces.
Spectinomycin is poorly absorbed in digestive tract. In 24 hours following oral
administration minor concentrations of the antibiotic are observed in kidneys, liver,
lungs, muscles and fat tissue. Spectinomycin binding to proteins does not exceed 10%.
Its concentration in blood serum reaches maximum in 4 hours. Spectinomycin is scarcely
biotransformed in the body and is excreted unchanged in feces.
Indications:
Treatment of hens (broiler chickens, brood hens, pullets) and swine against enzootic
pneumonia, salmonellosis, dysentery, MMA (mastitis-metritis-agalactia) syndrome,
necrotic enteritis, colibacillosis, mycoplasmosis and other diseases of digestive tract and
respiratory organs caused by lincomycin- and spectinomycin-sensitive microorganisms
Contra-Indication:
Do not use in combination with erythromycin.
Side effect:
In some cases, redness of the skin and mucous membranes may occur in swine after
drug administration, it does not require drug withdrawal.
Special precautions for administration:
Do not prescribe the drug in sub-therapeutic doses and animals with hypersensitivity
to the drug components.
The dissolved drug shall be used within 24 hours.
Whithdrawal Period:
Animal and poultry slaughter for meat is allowed in 3 days (swine) and 2 days
(broiler chickens, pullets and brood hens) following the last drug administration. Meat,
obtained before the mentioned term shall be utilized or fed to non-productive animals
depending on the statement of a veterinary physician.
Storage:
Store in a dry dark place out of the reach of children at 0-25 °С
