Parana COLIMOX ws
Each 1 g contains active ingredients:
colistin sulfate 1 200 000 IU
amoxicillin trihydrate 200 mg
Dosage:
Orally with drinking water in the following doses:
calves, goats and lambs under 3 months old: – 5 g of the drug (6,000,000 IU
of colistin sulfate and 1 g of amoxicillin trihydrate) per 100 kg of body weight, twice
a day for 3-5 days;
broiler chickens, swine: – 1 kg of the drug (1,200,000,000 IU of colistin sulfate
and 200 g of amoxicillin trihydrate) per 1000 liters of drinking water for 3-5 days.
The drug solution shall be the only source of drinking water throughout the whole
treatment period!
Description:
A combination of amoxicillin and colistin with synergistic action.
Colistin is a polymyxins antibiotic with bactericidal effect on gram-negative
microorganism (E.сolі, Salmonella spp., Pasteurella spp., Haemophіlus spp.,
Bordetella spp.). The mechanism of action of colistin consists in violation of
integrity of cytoplasmic membrane in bacteria. Colistin interacts with phospholipids
and penetrates inside, thus, it destroys the cell membrane structure. The bacterial
membrane permeability changes right after contact with the drug. Apart from
antibacterial effect, colistin binds phospholipid A and neutralizes toxic effect of
bacterial endotoxin.
Amoxicillin is a broad-spectrum semi-synthetic antibiotic of the penicillin
group. It has bactericidal effect against gram-positive (Corynebacterіum spp.,
Erysіpelothrіx spp., Clostrіdіum spp., Streptococcus spp., Staphylococcus spp.) and
gram-negative (E.сolі, Campylobacter spp., Actіnobacіllus spp., Haemophіlus spp.,
Pasteurella spp., Proteus mіrabіlіs, Salmonella spp.) microorganisms. It prevents synthesis of bacteria cell walls, inhibiting the activity of enzymes of transpeptidase and
carboxypeptidase, which causes osmotic balance disorders, resulting in death of
microorganisms at their growth stage.
Colistin is poorly absorbed from intestine in minor quantities, so it is effective in
treatment of diseases of digestive organs. In contrast to low concentrations of colistin in blood serum and tissues, its concentration in various segments of digestive
tract is constantly high. There is a higher concentration of colistin in the colon
and cecum than in the oral cavity. Colistin is almost non-systemic absorbed after
oral administration. 40% of colistin is unchanged in feces. 60% of colistin binds to
phospholipids and liposaccharides of gram-negative bacteria. It is primarily excreted in feces.
Amoxicillin when taken orally is absorbed from the digestive tract in greater amounts
than ampicillin. The bioavailability of amoxicillin is 60 – 70%. It is rapidly distributed
in body fluids, especially synovial fluid. Plasma protein binding is 37 to 38%. Half-life
period makes 0.7-1.4 hours. It is excreted primarily in bile.
Indications:
Treatment of calves, goatlings and lambs of up to 3 months of age, in swine and
broiler chickens of gastrointestinal diseases caused by amoxicillin- and colistin-sensitive microorganisms.
Special precautions for administration:
Do not administer to animals with hypersensitivity to drug components.
After preparation of the mother solution using water with high hardness, the
formation of turbidity or sediment is possible, which does not affect the
therapeutic efficacy of the drug.
Interaction with other drugs or other forms of interaction
Do not prescribe in combination with other antibacterials.
The action of colistin is inhibited by bivalent cations Ba2 +, Ca2 + and Mg2 +;
unsaturated fatty acids and ammonium compounds.
Withdrawal period:
Slaughter of animals and poultry for meat is allowed 11 days (calves, lambs, goats),
8 days (swine) and 3 days (broiler chickens) after the last drug application. Meat,
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obtained before the mentioned term, shall be utilized or fed to non-productive
animals depending on the statement of a veterinary.
Contra indications:
Do not administer to animals with hypersensitivity to colistin and amoxicillin as well
as to animals with liver and kidney disorders.
Do not administer in combination with ampicillin, chloramphenicol, tetracy-
clines, sulfonamides, cephalosporin antibiotics, macrolides and aminoglycoside
antibiotics.
Do not prescribe in combination with other antibacterials.
Do not administer for prevention.
Do not administer in ruminants with functionally developed fore stomachs, as well
as laying hens, whose eggs are used for human consumption.
Do not administer in rabbits, ants, hamsters or other small herbivores.
Precautions:
In case of the drug in the recommended doses, no side effects are observed.
Possible allergic reactions. In case of allergic reactions, the drug is discontinued and
antihistamines are prescribed to the animal; if necessary, carry out symptomatic
treatment.
Special precautions for administration
Do not administer to animals with hypersensitivity to drug components.
After preparation of the mother solution using water with high hardness, the
formation of turbidity or sediment is possible, which does not affect the
therapeutic efficacy of the drug.
Interaction with other drugs or other forms of interaction
Do not prescribe in combination with other antibacterials.
The action of colistin is inhibited by bivalent cations Ba2 +, Ca2 + and Mg2 +;
unsaturated fatty acids and ammonium compounds.
Storage:
Store in a dry dark place out of the reach of children at 5-30 °С.
Use the drug within 30 days following the initial sampling from the package
provided it is stored in a dry, dark place at 5-30 С.
Shelf life is 24 hours after dissolution in drinking water
