Parana DOX 10% oral
1 g of the drug contains:
Doxycycline (as hyclate) 100mg
Dosage:
Swine: 1 litre per 1000 litres of drinking water (100 ppm; 10 mg/kg body weight)
for 5 consecutive days.
Poultry:1 litre per 1000 litres of drinking water (100 ppm; 10 mg/kg body weight)
for 3 consecutive days.
Description:
Doxycycline is a bacteriostatic agent that acts by interfering with the bacterial
protein synthesis of sensitive species.
Doxycycline is a semi-synthetic tetracycline derived from oxytetracycline. It acts
on the subunit 30S of the bacterial ribosome, to which it is linked reversibly,
blocking the union between aminoacyl-tRNA (transfer RNA) to the mRNA-ribosome
complex, preventing the addition of new aminoacids into the growing peptide chain
and thus
interfering with protein synthesis.
Doxycycline is active against Gram-positive and Gram-negative bacteria.
Spectrum of activity:
Streptococcus spp.
Staphylococcus aureus
Chlamydia spp.
Mycoplasma spp.
Salmonella spp.
Pasteurella multocida
Bordetella bronchiseptica
Indications:
Chickens (broilers):
Prevention and treatment of chronic respiratory disease (CRD) and mycoplasmosis
caused by microorganisms sensitive to doxycycline.
Pigs:
Prevention of clinical respiratory disease due to Pasteurella multocida and Mycoplasma hyopneumoniae sensitive to doxycycline.
The presence of the disease in the herd should be established before treatment.
Contra indications:
Do not use in case of hypersensitivity to tetracyclines.
Do not use in animals with hepatic dysfunction.
Do not administer to laying birds four weeks before the start of lay and during lay.
Do not use during pregnancy or lactation.
Side effects:
Allergic and photosensitivity reactions can occur. Intestinal flora may be affected if
treatment is very prolonged, and this may result in digestive disturbance.
Withdrawal times:
– For meat & offal:
Chickens (broilers) : 7 days
Pigs : 7 days
– Eggs: Not permitted for use in laying birds producing eggs for human consumption.
